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Nutrition/Ergogenic Aids

(67) SALIDROSIDE INGESTION ENHANCES OXYGEN UPTAKE DURING HIGH-INTENSITY EXERCISE IN HEALTHY, YOUNG ADULTS

Thursday, July 13, 2023
12:00 PM – 1:30 PM East Coast USA Time
Location: Milano III-IV
Abstract Details:

Purpose: The purpose of this study was to examine the effects of salidroside ingestion on oxygen uptake in healthy, young adults.

Methods: Fifty subjects (30M, 20F; Mean ± SD; Age: 21 ± 4 y) completed this double-blind, placebo-controlled study. Subjects were randomized to a Salidroside (SAL; 30 mg/2x/day of SAL) or Placebo (PLA; 30 mg/2x/day of rice flour) group. Subjects completed an entry session followed by pre- (PRE) and post-testing (POST), which were 14 days apart and consisted of 3 visits at each timepoint. During the entry session, demographic information was collected and informed consent was obtained. Testing session 1 consisted of a treadmill test to determine peak oxygen consumption (VO2 peak). Subjects began ingesting their supplement the following day (Day 2). During testing session 2 (Day 3), subjects returned to perform a time-to-exhaustion (TTE) test on a treadmill having consumed their supplement 30 min prior. During the TTE test, subjects had their oxygen consumption measured during a protocol that consisted of 1.5-min work bouts at the speed associated with their VO2 peak at 10% grade followed by active recovery for 1.5 min at 2 mph at 8% grade. Intervals were completed until volitional exhaustion. After the conclusion of testing session 2 of pre-testing subjects continued supplementation throughout the remainder of the study. Subjects returned to the lab for post-testing 14 days after their first testing session of PRE. All procedures were repeated at POST, however, subjects consumed their supplement 30 min prior to each of their testing sessions. During the TTE tests, the percentage of predicted VO2 peak that was achieved during the trial was recorded. Every subject was able to complete at least three intervals, thus the first three intervals were compared individually between groups. Beyond that, subjects completing 5 or more intervals had their remaining intervals split in half and averaged as middle intervals and final intervals for analyses.

Results: Despite no significant interaction (TIME x GROUP; p = 0.19), TIME (p = 0.12), or GROUP (p = 0.41) effect, analysis of simple main effects indicated a significant increase from PRE to POST in peak absolute VO2 uptake for the SAL group (3220 ± 705 to 3314 ± 797 mL/min; p = 0.43), whereas no change was observed for the placebo group (3433 ± 666 to 3441 ± 727 mL/min; p = 0.86). There was no significant interaction (TIME x GROUP; p = 0.52 to 0.91) or TIME (p = 0.17 to 0.98) effect for Interval 1, Interval 2, Interval 3, Middle Intervals, or Final Intervals; therefore, the data were collapsed to compare groups. Group-wise comparisons revealed that SAL was able to reach a significantly higher percentage of VO2 peak during all work intervals (SAL vs. PLA; Interval 1: 74.7 ± 5.5% vs. 71.0 ± 5.4%, p < 0.001; Interval 2: 82.3 ± 5.5% vs. 79.4 ± 5.0%, p < 0.001; Interval 3: 84.9 ± 5.6% vs. 81.9 ± 5.4%, p = 0.001; Middle Intervals: 86.4 ± 5.2% vs. 82.9 ± 5.4%, p < 0.001; Final Intervals: 85.6 ± 5.0% vs. 83.4 ± 5.6%, p = 0.016).

Conclusions: Salidroside supplementation may beneficially alter oxygen uptake in healthy, young adults performing high-intensity interval training. PRACTICAL APPLICATION: Acute salidroside supplementation may be beneficial for athletes looking to enhance oxygen uptake during high-intensity exercise.

Acknowledgements: N. Schwarz received funding from Double Rainbow Biosciences to perform the study.